Clinical Application

This module investigates the safety and efficacy of two tDCS approaches in major depression, i.e. tDCS augmented psychotherapy (PoP trial, WP6, Malek Bajbouj, Berlin) and tDCS after non-response to pharmacotherapy (PoE trial, WP7, Frank Padberg, Munich). Both studies are randomized placebo-controlled multicenter trials (RCTs) which could directly lead to a wider clinical application, but also allow provide input into Modules A and B (reverse translation). Both trials also represent the final and critical step for testing the overall translational research strategy of the consortium.